Improving Experimental Design through Uncertainty Analysis

In this paper, the development of a fission-gas collecting and physical-analysis-enabling instrument was proposed for small-volume determination. Analysis specifications require design capable accurately repeatably determining volumes in range 0.07–2.5 mL. This system relies on series gas expansions originating from cylinder with known internal volume. The combined law is used to derive unknown these expansions. Initial designs included one two volumes, 11.85 ± 0.34 mL 5.807 0.078 mL, manifold volume 32 Results obtained modeling system’s operation showed that 0.07 can be determined relative expanded uncertainty greater than 300% (k = 2) single replicate, which unacceptable experimental design. connecting rodlet, i.e., volume, sensitivity pressure sensor were key contributors measured rodlet limited available options sensors, so emphasis placed final reduced 17 These changes design, replicate analysis, able reduce by ±12%